This is a 47 year old healthy male who had a chest radiograph for a chest injury. A nodule was seen in the LUL, and a CT was done. He does not smoke, nor had any exposure history. The CT images are shown. Does this require biopsy or is this a granuloma? It was not present on a CXR 5 years ago.
This is a 22 year old female with no prior respiratory complaints. She devloped a bronchitis in February and May, 2008 and had a CXR that suggested bullous disease in the RUL. PFT’s showed normal spirometry and the diffusion capacity was 89% predicted. She had no respiratory illness as an infant.
Her CT scan showed the following
Which of the following would you recommend?
1) Leave the bulla alone, no Rx recommended, inform to go to ED with SOB or pain
2) Recommend Scuba diving lessons to utilize hyperbaric conditions to shrink the bulla
3) Refer for an experimental endobronchial valve to deflate the bulla
4) Refer to thoracic surgery for surgical bullectomy
5) Insert a Heimlich valve to permit deflation of the bulla through chest wall
I include a reference regarding 1 way valves:valve
This 49 year old male had been healthy but presented with increasing SOB. Below are the radiographs in the first 6 days in the hospital
This 34 year old female presented for evaluation with 2 months of increasing shortness of breath, chest tightness and cough. There was minimal sputum production, but she is uncomfortable at night and had to sleep with 2 pillows. Wheezing had been present but she did not respond to steroids, albuterol or Symbicort. Her lab data was normal except for a positive mono test. She was not exposed to any aerosols. She is a non-smoking, non-drug using female with 2 children living in a rural enviroment.
The CT images are shown:
What are possible diagnoses and how would proceed at this time
The ground glass infilitrates were caused by alveolarseptal amyloidosis. The CT showed a uniformity of ground glass infiltrates, without a mosaic pattern. The pathology images above include H&E, congo red and crystal violet stains which are typically used to confirm the diagnosis. The fibrils were also birefringent but this could not be photographed. These were samples obtained by transbronchial biopsy.
This case was used as a clinical vignette for the 2nd year medical students. Above is the paper written by Nicholas Braus (click on the clinical-practice-essay icon) which is an excellent review of the pathophysiology of this disorder. I invite you to read it.
This patient is a 67 year old female who had a chronic right pleural effusion. A thoracentesis in March did not reveal a cause. She presented in May to HH with a pain in her left chest and increased sputum production for 2 weeks. A CT scan was done. What do you think was responsible for the air in the pleural space?